What is Vitamin K2?

Vitamin K is a fat-soluble vitamin. It is well known for its role in heart health, producing prothrombin necessary for blood clotting and preventing calcium build-up in the arteries. Vitamin K helps convert glucose into glycogen for storage in the liver and is essential for the formation, repair, and maintenance of healthy bones. Vitamin K2 as MK7 (menaquinone-7) is the most stable form and stays in the body longer than other vitamin K.

MK7 Vitamin K2: Building Strong Bones

The bone matrix contains osteoclasts (breakdown old and damaged bone tissue) and osteoblasts (bone building) that are responsible for breaking down and rebuilding healthy bones. Once osteoclasts remove damaged and old bone, the osteoblasts secrete the protein osteocalcin into the blood. Osteocalcin is activated by vitamin K2 and binds to calcium, transporting calcium from the blood to the bone. Osteoblasts then integrate the calcium into the bone matrix, working to increase bone mineral density and strength.

Every seven years, bone remodelling replaces all the bones in your entire body!

MK7 Vit K2: Cardiovascular Health

Vitamin K2 in the form of MK7 regulates the transportation and distribution of calcium in the entire body. Through the activation of specific carboxylated proteins, calcium is moved from the blood and bound into the bone matrix, thus helping to prevent calcium from building up and forming plaques in the arteries (a risk factor for heart disease).

Risk Factors for Vitamin K Deficiency:

Vitamin K deficiency is rare as the body makes K2 in the intestines. The main symptoms of deficiency include easily bruising and excessive bleeding.

• taking prescriptions including anticoagulants and antibiotics
• condition causing fat malabsorption (celiac disease, cystic fibrosis)
• breastfeeding infants
• disorder of the biliary tract (liver, gallbladder, bile ducts)

Why Supplement with MK7 Vitamin K2 + D3 Combined?

Vitamins K2 and D3 work synergistically to maintain bone health by enhancing calcium absorption into the bone matrix. Vitamin K2 allows the calcium in the bloodstream to be utilized for bone building. It transports excess calcium from the arteries and blood into the bone, where vitamin D3 helps absorption and binding the calcium into the bone matrix. Through supporting healthy bone, you reduce the risk of developing brittle bones and osteoporosis.

What is Vitamin D3?

Vitamin D is a fat-soluble vitamin. It is manufactured in the body and stored in fat cells after the skin is exposed to UV-B rays from direct sunlight. Vitamin D3 is best known for bone health and regulating immune function. In addition, the D3 form is biologically active and ready for use in a wide variety of vital biological processes within the body.

Vitamin D3: Building Strong Bones

Vitamin D3 is needed for development, growth, and maintenance of strong bones and teeth. It is required for calcium regulation, by promoting absorption of calcium and phosphorus from the small intestine and kidneys to be deposited for in bone mineralization. Additionally, when vitamin D is combined with calcium intake and regular weightbearing exercise, it helps reduce the risk of developing osteoporosis.

Deficiency can be associated with loss of bone density, osteoporosis and ‘brittle’ bones, lower back pain¹, and muscle weakness.

Vitamin D3: Healthy Immune Function

Vitamin D3 is required for proper immune function and can modulate both adaptive and innate immune responses. Vitamin D acts to facilitate immune system activity with receptors expressed on immunological cells (B-cells, T-cells and antigen presenting cells)5, and can stimulate NK lymphocytes and enhance suppressor T-cells.

Deficiency can be associated with an increased susceptibility to infection, autoimmune disease2 including MS, and certain types of neoplasia ³.

Risk Factors for Vitamin D Deficiency:

• Adults 50 years and older⁴
• Pregnancy & breastfed infants
• Limited sun or skin exposure (indoor, clothes)
• Higher melanin pigment in darker skin tone⁵ can block UV-B rays
• Sunscreen use can block up to 98% of UV-B rays⁶
• Season and geographical location
• Cloud cover and pollution
• Intestinal absorption issues

Why Supplement with Vitamin D3

Over 70% of Canadians are vitamin D deficient⁷, proving that it is difficult
to get enough vitamin D from direct sun exposure and food alone. Studies
show vitamin D is essential for long-term health and therefore a reliable and
consistent source of vitamin D (often through supplementation) is necessary
to prevent risk of deficiency. Optimal vitamin D levels are essential for health
throughout all ages and stages of life.

Vitamin D requirements change throughout life and according to risk factors⁸:

• Infants (up to 1 year): 400 IU daily (upper limit 1000 – 1500 IU)
• Children (1 to 9 years): 600 IU daily (upper limit 2500 – 3000 IU)
• Pregnancy and lactation: 600 IU daily (upper limit 4000 IU)
• Adults: 800 IU daily (upper limit 4000 IU)

Protocol: Rebuild Bone Density & Osteoporosis

Improve bone health by increasing bone strength and bone mineral density. The nutrients found in BoneSure, MK7 with D3 Drops, and Basictab increase bone mineral density and reduce the risk of developing osteoporosis.

Osteoporosis (brittle bones) is a condition where there is an impaired metabolism of the inorganic and organic bone mass. According to European Biological Medicine, increased acidification (metabolic acidosis) of the tissues can cause bone cell dysfunction and reduce bone mineral density. The bones serve as the mineral reservoirs in the body, providing a protective function to maintain normal systemic pH levels. When increased acidification occurs, calcium and other minerals from drawn from the bones and muscles to buffer the excess of acid (hydrogen ions), contributing to calcium and mineral loss from the bones.

Goals of the Bone Health Protocol:

1. Rebalance normal acid-base (pH) levels.
2. Reduce bone loss.
3. Rebuild bone mineral density.

Remedy

Dose

Monday to Sunday

BoneSure

2 capsules

two times a day

MK7 with D3

1 drop

once a day

Basictab

2 tablets

empty stomach, warm water, two times a day

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	Basictab 180 tablets Acid-Base Balance ✔ Restore pH balance ✔ Decrease acute inflammatory response ✔ Support beneficial intestinal flora ⋅ SKU: 35010850	Login for pricing
	BoneSure 90 capsules Bone Support, Bone Density, Osteoporosis ✔ Increase bone mineral density ✔ Reduce risk of osteoporosis ✔ Plant-based calcium with 97% absorption ⋅ SKU: 35011270	Login for pricing
	MK7 with D3 Drops 10 ml Bone, Osteoporosis, Cardiovascular, Immune • MK7 is the most stable form of vitamin K2 • K2 as MK7 drives calcium into the bone matrix • MK7 - high purity and stability • Highest amounts of MK7 & D3 per drop ✓ Build and maintain strong teeth and bone matrix ✓ Helps prevent Osteoporosis ✓ 360 drops per bottle ⋅ SKU: 35011365	Login for pricing
	Rebuild Bone Density Protocol Bundle Improve bone health ✔ Increase bone mineral density ✔ Plant-based calcium with 97% absorption ✔ Build and maintain strong teeth and bone matrix ✔ Restore pH balance ✔ Decrease acute inflammatory response Download this protocol PDF SKU: 35097155	Login for pricing

Bone Health Benefits

BONESURE _1,2,3

Recommended dosage (adult): 2 capsules two times daily. Safe to use long term.

BoneSure contains a combination of plant-sourced multi-minerals (from marine algae Lithothamnion corallioides), vitamins (C, D, K), boron, and 76 naturally occurring trace elements to provide full-spectrum remineralization and bone health.

• increased collagen formation.
• increase bone mineral density.
• support healthy bone formation.
• reduce the risk of developing osteoporosis.
• improve bone, strength, structure, and function.
• improve bone health in peri-menopausal and menopausal women.

MK7 WITH D3 DROPS _{3,4,10,11,12,13}

Recommended dosage (adult): 1 drop once daily. Safe to use long term.

MK7 with Vitamin D3 is a combination of vitamin K2 (MK7, menaquinone 7) and vitamin D3 to maintain bone health and improve calcium absorption and binding into the bone matrix.

• drives calcium into the bone matrix.
• promotes healthy bone mineral density.
• reduce the risk of developing osteoporosis.
• regulates calcium transportation and distribution.
• improve calcium and phosphorus absorption for bone health.

BASICTAB _{14,15,16,17,18,19}

Recommended dosage (adult): 2 tablets twice daily. Take with warm water on an empty stomach. Use for three to six months.

Addressing the root cause of osteoporosis starts with reversing metabolic acidosis and restoring normal pH levels through alkaline therapy (using NaHCO3 to increase serum bicarbonate levels in the blood), a diet high in alkaline foods, and a reduced protein diet.

• support bone health.
• decrease inflammation.
• rebalance acid-base and tissue pH levels.
• .halt the need to draw from the bone mineral reserves to buffer acidosis.

References

1. Ariane Viana de Souza e Silva, et al. Association of Back Pain with Hypovitaminosis D in Postmenopausal Women with Low Bone Mass. BMC Musculoskelet Disord. 2013 Jun 12;14:184.
2. Aranow Cynthia, MD. Vitamin D and the Immune System. J Investig Med. 2011 Aug; 59(6): 881–886.
3. Cedric F. Garland, DrPH, et al. The Role of Vitamin D in Cancer Prevention. Am J Public Health. 2006 February; 96(2): 252–261.
4. Office of Dietary Supplements. (2016). Vitamin D – Fact Sheet for Health Professionals. National Institutes of Health. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
5. Abdul Hameed, A., Akhtar, N. The Skin Melanin: An Inhibitor of Vitamin-D3 Biosynthesis: With Special Emphasis with Structure of Skin. A Mini Review. Department of Pharmacy and Alternative Medicine. Dermatology Case Reports, 2019, 4:1
6. Nair, R., Maseehm, A. (2012). Vitamin D: The “Sunshine” Vitamin. Journal of Pharmacology & Pharmacotherapeutics. Apr-Jun; 3(2): 118-126.
7. G K Schwalfenberg 1, S J Genuis, M N Hiltz. Addressing Vitamin D Deficiency in Canada: A Public Health Innovation Whose Time Has Come. Public Health. 2010 Jun;124(6):350-9.
8. Health Canada (2010). Vitamin D and calcium: Updated dietary reference intakes. Available online: http://www.hc-sc.gc.ca/fn-an/nutrition/vitamin/vita-d-eng.php
9. Gorman D.M.O., Tierney C.M., Brennan O., Brien F.J.O. The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro. Phyther. Res. 2012;380:375–380.
10. Aslam M.N., Kreider J.M., Paruchuri T., et al. A Mineral-Rich Extract from the Red Marine Algae Lithothamnion calcareum Preserves Bone Structure and Function in Female Mice on a Western-Style Diet. Calcif. Tissue Int. 2010;86:313–324.
11. Palacios C. The Role of Nutrients in Bone Health, from A to Z. Crit. Rev. Food Sci. Nutr. 2006;46:621–628.
12. Widaa A., Brennan O., Gorman D.M.O., Brien F.J.O. The Osteogenic Potential of the Marine-Derived Multi-Mineral Formula Aquamin Is Enhanced by the Presence of Vitamin D. Phyther. Res. 2014;684:678–684.
13. Brennan O, et al. A Natural, Calcium-Rich Marine Multi-Mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis. Calcified Tissue Int. 2017;101:445–455.
14. Gorman D.M.O., Tierney C.M., Brennan O., Brien F.J.O. The Marine-derived, Multi-mineral formula, Aquamin, Enhances Mineralisation of Osteoblast Cells In Vitro. Phyther. Res. 2012;380:375–380.
15. Zenk J.L., Frestedt J.L., Kuskowski M.A. Effect of Calcium Derived from Lithothamnion sp. on Markers of Calcium Metabolism in Premenopausal Women. J. Med. Food. 2018;21:154–158.
16. Shea, K.L., Barry, D.W., Sherk, V.D., et al. Calcium Supplementation and PTH Response to Vigorous Walking in Postmenopausal Women. Med Sci Sports Exerc. 2014; 46(10): 2007–2013.
17. Slevin, M.M., Allsopp, P.J., Magee, P.J, et al. Supplementation with Calcium and Short-Chain Fructo-Oligosaccharides Affects Markers of Bone Turnover but Not Bone Mineral Density in Postmenopausal Women. J Nutr. 2014;144(3):297-304.
18. Knapen, M.H.J, Drummen, N.E., Smit, E., Vermeer, C., Theuwissen, E. Three-year Low-dose Menaquinone-7 Supplementation Helps Decrease Bone Loss in Healthy Postmenopausal Women. Osteoporos Int. 2013;24(9):2499-507.
19. Aspray, T.J., Hill, T.R. Osteoporosis and the Ageing Skeleton. Subcell Biochem. 2019;91:453-476.
20. Chen, L., Hou, P., Chen, K. Nutritional Support and Physical Modalities for People with Osteoporosis: Current Opinion. Nutrients. 2019 Nov 20;11(12):2848.
21. Huang, Z-B, Wan, S-L, Lu, Y-J, et al. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015 Mar;26(3):1175-86.
22. Domrongkitchaiporn S., Pongskul C., et al. Bone histology and bone mineral density after correction of acidosis in distal renal tubular acidosis. Kidney Int. 2002;62:2160–2166.
23. Krieger N.S., Frick K.K., Bushinsky D.A. Mechanism of acid-induced bone resorption. Curr. Opin. Nephrol. Hypertens. 2004;13:423–436.
24. Abramowitz, M.K., Melamed, M.L., Bauer, C., Raff, A.C., Hostetter, T.H. Effects of Oral Sodium Bicarbonate in Patients with CKD. Clin J Am Soc Nephrol. 2013 May;8(5):714-20.
25. Siener., R. Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease. Nutrients. 2018 20;10(4):512.
26. Angeloco, L,R,N, de Souza, G.C.A, Romao, E, A., Chiarello, P.G. Alkaline Diet and Metabolic Acidosis: Practical Approaches to the Nutritional Management of Chronic Kidney Disease. J Ren Nutr. 2018 May;28(3):215-220.
27. Frassetto, L., Banerjee, T., Powe, N., Sebastian, A. Balance, Dietary Acid Load, and Bone Effects—A Controversial Subject. Nutrients. 2018 Apr; 10(4): 517.